�Two self-governing research groups have found that coincidental inhibition of two sign pathways resulted in substantially enhanced antineoplastic effects in mouse models of prostate and white meat cancer. In an follow commentary, Steven Grant, at Virginia Commonwealth University Health Science Center, Richmond, discusses the clinical importance of these studies and highlights some of the questions that still need to be answered.
In the first base study, Pier Paolo Pandolfi and colleagues, at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, and Memorial Sloan-Kettering Cancer Center, New York, report that tumour samples from patients with biopsy-accessible strong tumors of advanced disease treated with a drug that inhibits the mTOR signaling tract showed increased activation of the MAPK signaling footpath. Similar results were ascertained in a mouse modelling of prostate cancer undermentioned treatment with the same drug. As inhibition of the MAPK signaling nerve pathway enhanced the antitumoral personal effects of forbiddance of the mTOR sign pathway in mice transplanted with a human boob cancer cubicle line, the authors suggest that a combination therapy using drugs that object each footpath might amend the treatment of human cancers.
In the second sketch, Cory Abate-Shen and colleagues, at Columbia University College of Physicians and Surgeons, New York, and the University of Medicine & Dentistry of New Jersey, Piscataway, show that coincidental inhibition of the mTOR and MAPK signaling pathways inhibited the in vitro growth of prostate crab cell lines and the in vivo growth of prostate tumors in a mouse modeling of prostate gland cancer. This was in particular true in a manakin of highly aggressive and frequently deadly forms of the disease, which do not reply to endocrine deprivation therapy, leading the authors to suggest that this combination therapy might be peculiarly useful for treating patients with advanced, hormone-refractory prostate cancer.
TITLE: Inhibition of mTORC1 leads to MAPK nerve pathway activation through a PI3K-dependent feedback loop in human cancer
AUTHOR CONTACT:
Pier Paolo Pandolfi
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
View the PDF of this article at: https://www.the-jci.org/article.php?id=34739
RELATED MANUSCRIPT
TITLE: Targeting AKT/mTOR and ERK MAPK signal inhibits hormone-refractory prostate cancer in a preclinical mouse model
AUTHOR CONTACT:
Cory Abate-Shen
Columbia University College of Physicians and Surgeons, New York, New York, USA.
View the PDF of this article at: https://www.the-jci.org/article.php?id=34764
ACCOMPANYING COMMENTARY
TITLE: Cotargeting survival signaling pathways in cancer
AUTHOR CONTACT:
Steven Grant
Virginia Commonwealth University Health Science Center, Richmond, Virginia, USA.
View the PDF of this article at: https://www.the-jci.org/article.php?id=36898
Source: Karen Honey
Journal of Clinical Investigation
More info
Monday, 8 September 2008
Tuesday, 19 August 2008
U.S. Women Significantly Increase Use Of Contraceptive Services
�Using across the country representative appraise data, researchers examined the patterns and trends in the use of sexual and generative health care services in U.S. women aged 15 to 44 between 1995 and 2002. The results conclude that the receipt of contraceptive device services (a birth control method or a prescription) among American women rose significantly during the time of this study (1995-2002) from 36 percent to 41 pct; however the overall reception of sexual and procreative health care services remained constant, with 74 per centum of U.S. women reportage receipt of such services.
"Possible explanations for this trend include both increased demand for contraceptive services (e.g., because of changing contraceptive use patterns) and improved financial accessibility of contraceptive care within the secret sector (e.g., because of bettor insurance coverage of contraceptive services)," the study's author inferred.
From: "Trends in U.S. Women's Use of Sexual Reproductive Health Care Services, 1995-2002"
The American Journal of Public Health is the monthly Journal of the American Public Health Association (APHA), the oldest and most diverse organization of populace health professionals in the world. APHA is a leading publisher of books and periodicals promoting sound scientific standards, action programs and populace policy to enhance wellness.
American Public Health Association
More info
"Possible explanations for this trend include both increased demand for contraceptive services (e.g., because of changing contraceptive use patterns) and improved financial accessibility of contraceptive care within the secret sector (e.g., because of bettor insurance coverage of contraceptive services)," the study's author inferred.
From: "Trends in U.S. Women's Use of Sexual Reproductive Health Care Services, 1995-2002"
The American Journal of Public Health is the monthly Journal of the American Public Health Association (APHA), the oldest and most diverse organization of populace health professionals in the world. APHA is a leading publisher of books and periodicals promoting sound scientific standards, action programs and populace policy to enhance wellness.
American Public Health Association
More info
Saturday, 9 August 2008
Sony buys Bertelsmann out of Sony BMG - home to Mark Ronson and Bruce Springsteen
Japanese electronics giant Sony is purchasing its collaborator Bertelsmann out of their Sony BMG music articulation venture, home to artists including Mark Ronson and Bruce Springsteen, in a deal worth $1.2bn (�614m) to the German media group.
The move, which has been rumoured for some months, could ply Bertelsmann with the financial firepower to buy all or part of BSkyB's controversial 17.9% stake in ITV.
There has been persistent utter that Bertelsmann's RTL business, which owns Five in the UK, is concerned in purchasing up Sky's stake. The competition charge demanded that the stake be reduced to under 7.5% and Sky launched an appeal. While waiting for the outcome of that appeal, Sky is understood to ingest received informal approaches from a bit of potential difference buyers.
These ar rumoured to have included TV manufacturer Endemol, Italy's Mediaset and Israeli-American media mogul Haim Saban as well as RTL.
Sony has been negotiating with Bertelsmann for some months nearly acquiring control of Sony BMG, which they created in August 2004 by pooling their music labels.
Sony BMG already had $600m in cash on its balance sheet, which was split evenly between the two owners. Bertelsmann will take all that hard cash, plus Sony is paying a further $600m for the business.
Sony BMG will now become Sony Music Entertainment Inc (SMEI). As part of the dealing, the parties have likewise agreed to continue to share the company's fabrication and distribution requirements betwixt Sony's manufacturing subsidiary, Sony DADC, and Bertelsmann's services company, Arvato Digital Services by extending the agreements with Arvato for extra terms of up to six long time. In addition, Bertelsmann will be taking over selected European music catalogue assets from Sony BMG.
"Music has been a vital and vibrant part of Sony's culture for over 20 years," said Sir Howard Stringer, president and CEO, Sony Corporation. "This acquisition will let us to achieve a deeper and more robust integration between the wide-ranging global assets of the music companionship and Sony's products, in operation companies and affiliates. It enables us to offer a total entertainment have to consumers,"
Bertelsmann refused to say what it intends to do with the hard cash raised.
"After a careful and thorough review, we made the strategical decision to sell our investment in this articulation venture to Sony, a step that we believe will benefit the stakeholders of both our companies," stated Hartmut Ostrowski, chairperson and CEO of Bertelsmann. "This locomote is reproducible with our new growth strategy and will enable us to focus on our defined growth areas. Sony has been an excellent collaborator, and they are the right company to take aim this patronage to the next dance step and assure that it realizes its full value and electric potential. We look forward to witnessing Sony Music Entertainment's exciting future under Sony's ownership."
Once the transaction is completed, Sony Music Entertainment will include Arista Records, Columbia Records, Epic Records, J Records, Jive Records, RCA Records and Zomba. Key recording artists will include Celine Dion, Alicia Keys, Yo-Yo Ma, Bruce Springsteen, Justin Timberlake, Usher and Jay Chou.
More info
Tuesday, 1 July 2008
50 Cent locked in bitter legal battle with his ex
The title of rapper 50 Cent's new musical project - release date yet to be confirmed - is Before I Self-Destruct. Given the storm clouds gathering over the star's private life, an early distribution of the album may be advisable.The rapper - real name Curtis Jackson - has placed the launch on hold while he fights Shaniqua Tompkins, the mother of his young son, in a case which has begun to plumb rare depths of bile and bitterness.In the latest twist, the singer filed a �10 million ($26 million) defamation lawsuit against his ex-girlfriend last week. That move appears to be an act of retaliation against a temporary restraining order sought by Tompkins, requiring him to surrender all firearms and keep away from her.America's hottest rap star already bears the scars from nine gunshot wounds. The mental bruising from his battle with Tompkins may prove as permanent.The core of the dispute relates to the �25 million Long Island mansion occupied by Tompkins and her 11-year-old son by Jackson, Marquise. Police are investigating the possibility that a fire, which destroyed the property and left Tompkins and five others in hospital, was deliberate.
Jackson has said he finds it inappropriate that Tompkins was living in his house with her new boyfriend and several other people. But he vehemently denies any involvement in the blaze. The day before the fire, Tompkins was seen arguing with Jackson near the house, having recently taken the star to court to secure her right to stay in the property. The warring couple went to mediation where there was a fight between the rapper's bodyguard, Tompkins' current boyfriend and some other acquaintances.A New York judge has ordered Jackson to hold on to the property ruins and place any insurance proceeds he receives into a trust account pending the outcome of Tompkins' �25 million lawsuit against him. She is also pursuing a claim that Jackson promised her half of his earnings for life.The rapper has responded that his ex-partner has "a sense of entitlement because she was around during that time period when I didn't have much ... she has a [designer] bag habit that costs more than the child support".According to Tompkins, the rapper is still fixated with her. "If he can't have me he feels like no one can. He's obsessed. He's very obsessed. We're in litigation, we're fighting over the house. He said he was gonna have someone come kill me ... " - OBSERVER
Jackson has said he finds it inappropriate that Tompkins was living in his house with her new boyfriend and several other people. But he vehemently denies any involvement in the blaze. The day before the fire, Tompkins was seen arguing with Jackson near the house, having recently taken the star to court to secure her right to stay in the property. The warring couple went to mediation where there was a fight between the rapper's bodyguard, Tompkins' current boyfriend and some other acquaintances.A New York judge has ordered Jackson to hold on to the property ruins and place any insurance proceeds he receives into a trust account pending the outcome of Tompkins' �25 million lawsuit against him. She is also pursuing a claim that Jackson promised her half of his earnings for life.The rapper has responded that his ex-partner has "a sense of entitlement because she was around during that time period when I didn't have much ... she has a [designer] bag habit that costs more than the child support".According to Tompkins, the rapper is still fixated with her. "If he can't have me he feels like no one can. He's obsessed. He's very obsessed. We're in litigation, we're fighting over the house. He said he was gonna have someone come kill me ... " - OBSERVER
Tuesday, 24 June 2008
LiveDaily News Break Podcast, June 17: Coldplay, KISS, The Black Keys and more
Today's LiveDaily News Break podcast features news and tour information about KISS [ tickets ], Dolly Parton [ tickets ], The Black Keys [ tickets ] and Billy Idol [ tickets ]. We'll also list off some of the new albums arriving in stores today.
Monday, 9 June 2008
The Rolling Stones' Mick Jagger vs Dylan Thomas biopic
The Rolling Stones' Mick Jagger has threatened to sue BBC Films, who are behind the forthcoming Dylan Thomas biopic, 'The Edge Of Love'.
The singer owns the rights to large chunks of the Welsh poet's works, and is planning a biopic about the man himself through his production company, Jagged Films.
Jagger forced the producers of 'The Edge Of Love', which will star Keira Knightly and Sienna Miller, to edit out scenes featuring material from the prose collection 'Map Of Love'.
"We had access to a few of his Thomas' poems," the film's director, John Maybury, told The Independent. "Unfortunately Mick Jagger owns quite a lot and he has his own Dylan Thomas film project.
"There were parts of the set where we used elements of 'Map Of Love' but we had to CGI them out because Mick threatened to sue if we kept them in there."
The singer owns the rights to large chunks of the Welsh poet's works, and is planning a biopic about the man himself through his production company, Jagged Films.
Jagger forced the producers of 'The Edge Of Love', which will star Keira Knightly and Sienna Miller, to edit out scenes featuring material from the prose collection 'Map Of Love'.
"We had access to a few of his Thomas' poems," the film's director, John Maybury, told The Independent. "Unfortunately Mick Jagger owns quite a lot and he has his own Dylan Thomas film project.
"There were parts of the set where we used elements of 'Map Of Love' but we had to CGI them out because Mick threatened to sue if we kept them in there."
Monday, 2 June 2008
La Banda el Recodo
Artist: La Banda el Recodo
Genre(s):
Latin
Discography:
Puras Pa' Parrandear
Year: 2007
Tracks: 20
Lo Mejor de Mi Vida (cd2)
Year: 2002
Tracks: 10
Lo Mejor de Mi Vida (cd1)
Year: 2002
Tracks: 10
De Parranda Con La Banda
Year: 1999
Tracks: 10
La Banda el Recodo is non only when one of Mexico's almost successful banda, just one of the most eclecticist. Over the past tense quartet decades, the mathematical group has performed a concoction of Latin dance tunes, malarky swing, and classic music. The commencement banda to be recorded, La Banda el Recodo has recorded more than 178 records and has brought its music from the barrios of Mexico to the international phase.
Formed in 1951, La Banda el Recodo was conceived by self-taught clarinet actor Don Cruz Lizárraga (born July 1, 1918; died June 17, 1995). Although his formal teaching over after his first year of junior high school, Lizárraga was a headmaster as a player and bandleader. Teaching himself to play clarinet, against the wishes of his father, Lizárraga had to sell one of his pigs to raise the depressed payment for his first-class honours degree legal document. He elevated the extra price by picking corn for a neighbour. In the early '50s, Lizárraga united a banda de musica sinaloense, step by step decent the group's director. Shortly afterward moving to Mazatlan, Sinoloa, he accepted an invitation to sign with RCA Victor. Although he recorded his first 2 tunes, "Mi Adoracion" and "El Callejero," with a quintet, he soon formed La Banda el Recodo with its classic lineup of 2 clarinets, deuce huntsman's horn, 2 trombones, bass drum, and snare drum.
Lizárraga continued to tether La Banda el Recodo until his last from cancer in 1995. The mathematical group continues to tour, even so, light-emitting diode by his clarinetist sons German and Alfonso. The stream band also features clarinet musician Alberto Montoya, vocalists Carlos Sarabia and Luis Antonio Lopez, harmony singers VÃctor Manuel, Sarabia Garcia, and Aldo Sarabia Garcia, trumpet players Mario Alvarado Villaseñor and Enrique Valdez Rojas, sea bass drummer Jose Martinez Ochoa, snare drummer Jose Martinez Jimenez, trombone players Oscar Alvarez Otonez, Conrado Zatarain Fajardo, and Gerardo Urias Gutierrez, and sousaphone participant Carlos Soto Beltran. Five old age after the death of Lizárraga, La Banda el Recodo north Korean won a Grammy for Best Banda Performance for "Lo Mejor de Mi Vida" at the first base annual Latin Grammy Awards. Under the modern leaders of Lizárraga's sons, Alfonso and Joel, La Banda el Recodo bad ahead, prolifically releasing albums in the new millennium, including 2006's Mas Fuerte Que Nunca, which interracial banda with other musical influences, including salsa and cumbia.
Tuesday, 27 May 2008
Stone the Crows
Artist: Stone the Crows
Genre(s):
Rock
Discography:
Year of the Crow
Year: 2006
Tracks: 13
Stone the Crows was a tough luck, working class, progressive soul ring that came out of the pubs of Scotland in the early '70s. They had everything going away for them at the start: non one, merely iI gamey singers, a talented guitar player, a cycle section that had played with John Mayall, and the describe recognition of having Led Zeppelin director Peter Grant as their producer. Despite favourable reviews by the critics, however, they ne'er managed to sell their hybridized soulfulness music to a large audience. In addition, they bemused deuce of their key members early on, one of whom was tragically electrocuted, and the grouping skint up after 4 albums.
Their biggest contribution to rock was the vast vocal talent of one Maggie Bell. Winner of respective Top Girl Singer awards in Britain, Bell had a salacious, gutbucket voice that, although it felled seam unretentive of the naked emotion and range of Janis Joplin's, came in all likelihood closer to her style than any other female isaac Merrit Singer. She first-class honours degree attracted observance when she jumped up on stage at a express in Glasgow to roar with Alex Harvey of the Sensational Alex Harvey Band. Impressed by her natural endowment (and audacity), Harvey drug-addicted her up with his guitar-playing younger brother Les, then fronting a local striation called the Kinning Park Ramblers. After playing ground forces bases in Europe for respective eld as Power, Bell, Harvey, bassist Jim Dewar, keyboardist Jon McGinnis, and drummer Colin Allen (wHO had played with next bass player Steve Thompson in John Mayall's lot), came to the attention of Peter Grant and they changed their key out to Stone the Crows, which supposedly is a Scottish variation of "the infernal region with it."
Both of their low deuce albums received full reviews upon release, just sold very stingy. Then bassist/vocalist Jim Dewar resign the set to unite Robin Trower's entrant group, to be replaced by the non-singing Steve Thompson. Shortly afterward cathartic Teenaged Licks, guitar player Les Harvey was electrocuted onstage during a gig at Swansea University. This appeared to end the set, but they carried on, recruiting young Jimmy McCulloch from Thunderclap Newman and released "'Ontinuous Performance." Although the rock urge lauded the vocalizing of Bell, her group couldn't seem to emerge from the shadows and they stony-broke up afterward this last album, with McCulloch flying aside to unite Paul McCartney in Wings.
Friday, 9 May 2008
Tuesday, 29 April 2008
Williams breaks silence on Heath Ledger death
Williams breaks silence on Heath Ledger death
Actress Michelle Hiram King Williams has spoken publicly for the number one time since the death of her former pardner Heath Ledger expression "my heart is broken."
In a short financial statement: Williams said: "Please regard our demand to sorrow privately. My marrow is broken."
The mother of Ledger's two-year-old horse daughter Matilda added: "I am the mother of the well-nigh tender-hearted, high-spirited, beautiful little girl world Health Organization is the expectoration image of her male parent. Altogether that I can cling to is his presence inside her that reveals itself every solar day.
"His phratry and I watch Matilda as she whispers to trees, hugs animals, and takes steps deuce at a time, and we know that he is with us still. She will be brought up in the best memories of him."
Australian principal Leger died in Newly York stopping point month at the eld of 28. Results of the toxicology tests, which will watch the drive of his decease, are expected in the approach years.
Steve Roach, Jorge Reyes and Suso Saiz
Sunday, 27 April 2008
Ike Turner died from cocaine overdose
Ike Turner died from cocaine overdose
Soul isaac Bashevis Singer Dwight Eisenhower Turner died from a cocain o.d., according to the San Diego County health check examiner.
The 76-year-old was ground dead at his place virtually San Diego on 12 December last year.
The medical examination tester yesterday said that an pM proved that a long history of cardiovascular disease and pulmonary emphysema had contributed to the star's death.
Turner reportedly had a history of cocain addiction stretch over 30 years.
Van Der Graaf Generator
Agricantus
Artist: Agricantus
Genre(s):
New Age
Discography:
Ethnosphere Vol. 2
Year: 2001
Tracks: 8
Faiddi
Year: 1999
Tracks: 10
Tuareg
Year: 1996
Tracks: 11
Gnanzo!
Year: 1993
Tracks: 10
Kaleidos
Year:
Tracks: 11
Ethnosphere Vol. 1
Year:
Tracks: 8
The Palermo, Italy-based worldbeat grouping Agricantus took their name from the Latin locution for "song of the pale yellow fields"; their rank includes Giuseppe Panzeca (vocals, mandolins, sitar, early stringed instruments), Tonj Acquaviva (keyboards, samples/programming, vocals, and a vast array of percussion surgical incision instruments) Rosie Wiederkehr (guitar, vocals, samples/programming), Mario Rivera (bass, keyboards, vocals, samples/programming), and Antonjo Corrado (guitar, keyboards). Agricantus' euphony combines a dizzying array of traditional human beings euphony forms from crosswise the globe non merely with for each one other, only with club-ready electronic dance grooves, producing a compelling juxtaposition 'tween old and birthday suit. Their first base U.S. handout was the 1999 compiling The Best of Agricantus.
Jessica Simpson approves of Ashlee’s engagement
Jessica Simpson approves of Ashlee’s engagement
Jessica Simpson approves of sister Ashlee’s interlocking to Fall down Out Boy cradle Pete Wentz.
“My sister is overflowing with joy. Pete is an incredible soul. They naturally bring come out the c. H. Best in each other. I couldn’t be happier,” says Jessica.
Ashlee, 23, and Pete, 28, confirmed their engagement Wednesday, with a message on the friendsorenemies.com web site, “We know thither has been a lot of speculation lately about Pete and I, and we wanted our fans to be the first to acknowledge, because you guys ar the c. H. Best. Yes, we are thrilled to portion that we are happily engaged.”
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